The issue with wildcards is that they clash with the results done with ordinary probability calculation.  In fact, the usage of wildcards makes the hand formation a bit less competitive and of course, it can bring in an alarming victory to someone who would not have won if wildcards were not allowed for the game.  Wildcards are definitely placeholders in poker hands especially for the lucky folk who have been dealt with at least on of the declared wildcards in the pockets.

For example in a game where there is going to be more than one option for a play poker to make a valuable hand without wild cards, then if wildcards have been allowed in the same then the results of discarding the rest than the valuable high pair might have to be calculated by considering the wildcards allowance in the game.

Apart from wildcards influencing the consequences of a game, there are going to be yet more factors that will influence the overall output of the game:-
•    Position becomes less important in cases of wildcards and loose passive playing because it might be difficult to judge the implications and advantages of being in opponent flood of loose passive and wildcards game.  Things are going to be super-confusing when these two things get together.
•    The cost of risks can be dramatically fruitful or surprisingly a bad beat in cases where the game is being played with wildcards.
•    Like in any other game, the number of players that are heads up counts a danger symbol and more risk.  The less number of players that are heads up, the less will be the confusion in the table. Fewer players means more focus on the exact opponent.
•    Undeniably, regardless of whether you play a game with wildcards or without wildcards if you are going to fold a hand that is not worth the end hand formation, then you are going to have a better edge against all kinds of opponents and all variants of poker.

Though there can be a lot of frustrating mess in calculating wild cards one might think of skipping the odds calculation idea; however, it is not really necessary to make a mess of totally neglecting it.  A total plus or minus 5 value to the result will be a safe way to go, which means make the calculations like you would for the variant for a normal game, but just consider the +5 or -5 chance of dilution of the result due to the presence of wildcards.